Real World Reference
Betsy is a Healomancer. Healing powers coming from gods or Heaven is a well-known trope.
The phrases "Heavens to Betsy" and "Heavens to Murgatroyd" are both established expressions of surprise. The latter was first spoken in the 1944 film Meet the People, and became famous when used by the Hanna-Barbera cartoon character Snagglepuss. The former may have appeared in the late 19th century.